Cerebral angioarchitecture and perinatal brain lesions in premature and full-term infants.

The present study explains the time sequence and the location of the different ischemic perinatal brain lesions by the changes in the arterial angioarchitecture which take place during the last fetal months. Hemorrhages in the germinal layer and in the subarachnoid space occur at a time when, and in a localization where, the primitive embryonic type of arterial angioarchitecture is in regression, while leukomalacia lesions occur when the periventricular arterial border-zones are already formed.