Dykes R W
Ann Plast Surg. 1984 Nov;13(5):412-22. doi: 10.1097/00000637-198411000-00009.
Experiments in primates suggest that the skin senses are served by distinct classes of sensory receptors that relay their messages to the cortex on separate and parallel paths. When a peripheral nerve is transected and repaired, each sensory receptor that becomes reinnervated is innervated by a member of the class of axons that originally served that receptor. This specificity of reconnection allows the appropriate classes of sensations to be transmitted again from the skin to the cortex. However, sensory experiences are not completely normal because the regenerated axons have lost their previous spatial relationships and convey a spatially disordered message. Recent experiments suggest that the maps in the somatosensory cortex can respond to alterations of the somatosensory input in a manner that may compensate for some of the deficits produced by nerve injuries. There are, however, severe constraints on this reorganization, including restrictions to a cytoarchitectonic area, restrictions by certain boundaries within the somatotopic maps, and a requirement that a minimal topological order exist in the regenerated peripheral nerve.
灵长类动物实验表明，皮肤感觉由不同类型的感觉受体提供服务，这些受体通过独立且平行的路径将信息传递至皮层。当外周神经被切断并修复时，每个重新获得神经支配的感觉受体都由最初为该受体服务的轴突类别的一个成员进行支配。这种重新连接的特异性使得相应类别的感觉能够再次从皮肤传递至皮层。然而，感觉体验并不完全正常，因为再生的轴突失去了先前的空间关系，并传递了空间紊乱的信息。最近的实验表明，体感皮层中的图谱能够以一种可能补偿神经损伤所产生的一些缺陷的方式，对体感输入的改变做出反应。然而，这种重组存在严重限制，包括对细胞构筑区域的限制、在躯体定位图谱内某些边界的限制，以及再生外周神经中必须存在最小拓扑顺序的要求。
