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[绵羊奥斯特他线虫病的病理生理学。环形奥斯特他线虫实验性感染对作为皱胃功能指标的各项参数的影响]

[Physiopathology of ovine ostertagiasis. Effects of experimental infection by Ostertagia circumscripta on various parameters as indicators of abomasum function].

作者信息

Dakkak A, Khallaayoune K

出版信息

Ann Rech Vet. 1984;15(3):319-24.

PMID:6517474
Abstract

The measurement of the pH and Na+, K+, Ca++ and Cl- concentrations of the stomach or the abomasal contents allow the functioning statement of these organs to be determined. In the present work, these parameters were measured, at 2 day intervals, in six lambs fitted with permanent abomasal cannulae and experimentally infected with 150 000 O. circumcincta infective larvae. Infection was followed by a significant (P less than 0.01) increase in pH and Na+ and Ca++ concentrations, and a significant (P less than 0.01) decrease in K+ and Cl- concentrations of the abomasal contents. The disorders start when the 4th stage larvae begin to emerge from the mucosae (from the 4th to the 12th day infection) and become more marked between the 16th and the 32nd day; this means when the egg output starts and becomes marked. The disturbances noted in the present work suggest: 1) a defective working of HCl production mechanism; 2) an intraluminal diffusion of the interstitial liquid; 3) a stimulation of pepsin production. These disorders would have consequences on the functioning of the other parts of the digestive tract.

摘要

测量胃或皱胃内容物的pH值以及Na+、K+、Ca++和Cl-的浓度,可以确定这些器官的功能状态。在本研究中,对6只安装了永久性皱胃套管并经实验感染150000个环形泰勒虫感染性幼虫的羔羊,每隔2天测量一次这些参数。感染后,皱胃内容物的pH值、Na+和Ca++浓度显著升高(P<0.01),K+和Cl-浓度显著降低(P<0.01)。这些紊乱在第4期幼虫开始从黏膜中出现时(感染后第4至12天)开始,并在第16至32天之间变得更加明显;这意味着虫卵排出开始并变得明显时。本研究中观察到的紊乱表明:1)盐酸产生机制存在缺陷;2)组织液在管腔内扩散;3)胃蛋白酶产生受到刺激。这些紊乱会对消化道其他部分的功能产生影响。

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