Kostial K, Kargacin B, Blanusa M, Landeka M
Arch Toxicol. 1984 Oct;55(4):250-2. doi: 10.1007/BF00341020.
The effectiveness of DMPS (sodium 2,3-dimercaptopropane-1-sulfonate) in reducing inorganic mercury retention was studied in 2-, 6-, and 28-week-old albino rats. 203Hg was administered IP. The chelating agent DMPS was administered by IP injection at a dose of 250 mumol/kg body weight three times, 1 day after 203Hg administration and at 24 h intervals thereafter. The whole body retention determined 1, 2, 3, and 6 days after 203Hg administration showed that DMPS decreased the body retention of mercury in all age groups, being about twice as effective in adult compared to suckling rats. The reduced effectiveness was due to the reduced efficacy of DMPS in reducing kidney retention in young animals. In other organs the effectiveness of DMPS was not age dependent. These and previous results obtained with different chelating agents and other metals indicate that age might be an important factor in chelation therapy in general.
在2周龄、6周龄和28周龄的白化大鼠中研究了二巯丙磺钠（DMPS）降低无机汞潴留的有效性。腹腔注射给予203Hg。螯合剂DMPS通过腹腔注射给药，剂量为250μmol/kg体重，共三次，在给予203Hg后1天给药一次，此后每隔24小时给药一次。在给予203Hg后1天、2天、3天和6天测定的全身汞潴留情况表明，DMPS降低了所有年龄组大鼠体内的汞潴留，与乳鼠相比，成年大鼠体内汞潴留的降低效果约为其两倍。降低的有效性是由于DMPS在降低幼龄动物肾脏汞潴留方面的功效降低。在其他器官中，DMPS的有效性与年龄无关。这些以及之前使用不同螯合剂和其他金属获得的结果表明，一般来说，年龄可能是螯合疗法中的一个重要因素。
