用二巯基丙磺酸钠（二巯丙磺钠）去除体内沉积的金。
Removal of internally deposited gold by 2,3-dimercaptopropane sodium sulphonate (Dimaval).
作者信息
Gabard B
出版信息
Br J Pharmacol. 1980 Apr;68(4):607-10. doi: 10.1111/j.1476-5381.1980.tb10850.x.
Abstract
1 Orally administered 2,3-dimercaptopropane sodium sulphonate (DMPS, Dimaval) reduced the concentration of gold in rats treated with Auro-Detoxin and increased the urinary excretion of the metal. 2 In a long-term experiment, DMPS decreased significantly the concentration of gold in the kidneys and in the skin and increased it in plasma. 3 DMPS appears to be of interest as a possible antidote to gold, which could replace the more toxic 2,3-dimercaptopropanol (BAL).
摘要
1 口服2,3 - 二巯基丙烷磺酸钠（DMPS，二巯丙磺钠）可降低用金解毒素治疗的大鼠体内的金浓度，并增加金属的尿排泄量。2 在一项长期实验中，DMPS显著降低了肾脏和皮肤中的金浓度，并提高了血浆中的金浓度。3 DMPS作为一种可能的金解毒剂似乎值得关注，它可以替代毒性更强的2,3 - 二巯基丙醇（BAL）。
相似文献
1
Removal of internally deposited gold by 2,3-dimercaptopropane sodium sulphonate (Dimaval).用二巯基丙磺酸钠（二巯丙磺钠）去除体内沉积的金。
Br J Pharmacol. 1980 Apr;68(4):607-10. doi: 10.1111/j.1476-5381.1980.tb10850.x.
2
The effect of 2,3-dimercaptopropane sodium sulfonate on mercury retention in rats in relation to age.2,3-二巯基丙磺酸钠对不同年龄大鼠汞潴留的影响
Arch Toxicol. 1984 Oct;55(4):250-2. doi: 10.1007/BF00341020.
3
2,3-Dimercaptopropane-1-sodium sulfonate for reducing retention of ingested 203Hg in suckling rats.2,3-二巯基丙烷-1-磺酸钠用于降低乳鼠摄入的203汞的潴留量。
Bull Environ Contam Toxicol. 1988 Aug;41(2):185-8. doi: 10.1007/BF01705428.
4
The effect of immediate and delayed treatment with 2,3-dimercaptopropane-1-sulphonate on the distribution and toxicity of inorganic mercury in mice and in foetal and adult rats.2,3-二巯基丙烷-1-磺酸盐即时和延迟治疗对小鼠以及胎儿和成年大鼠体内无机汞分布和毒性的影响。
Acta Pharmacol Toxicol (Copenh). 1980 Feb;46(2):81-8. doi: 10.1111/j.1600-0773.1980.tb02425.x.
5
Note on the metabolism of the mercury chelating agent sodium 2,3-dimercaptopropane-1-sulfonate.关于汞螯合剂2,3-二巯基丙烷-1-磺酸钠代谢的说明
J Toxicol Environ Health. 1979 Jul;5(4):759-64. doi: 10.1080/15287397909529785.
6
Chelation in metal intoxication. XV: Influence of dimercaptopropane sulphonate (DMPS) on lead poisoned rats with normal or damaged kidneys.金属中毒中的螯合作用。第十五部分：二巯基丙烷磺酸盐（DMPS）对肾脏正常或受损的铅中毒大鼠的影响。
Ind Health. 1985;23(1):17-24. doi: 10.2486/indhealth.23.17.
7
Chelation of lead with DMPS and BAL in rats injected with lead.用二巯基丙磺酸钠（DMPS）和二巯基丙醇（BAL）对注射铅的大鼠进行铅螯合。
Bull Environ Contam Toxicol. 1983 Feb;30(2):165-9. doi: 10.1007/BF01610116.
8
Chelation of lead by dimercaptopropane sulfonate and a possible diagnostic use.二巯基丙烷磺酸盐对铅的螯合作用及一种可能的诊断用途。
Toxicol Appl Pharmacol. 1984 Mar 15;72(3):550-6. doi: 10.1016/0041-008x(84)90132-7.
9
10
DMPS (2,3-dimercaptopropane-1-sulfonate, dimaval) decreases the body burden of mercury in humans exposed to mercurous chloride.二巯基丙磺酸钠（2,3-二巯基丙烷-1-磺酸钠，二巯丙磺钠）可降低接触氯化亚汞的人体中的汞负荷。
J Pharmacol Exp Ther. 1998 Oct;287(1):8-12.
引用本文的文献
1
2,3-Dimercapto-1-propanesulphonate in heavy metal poisoning.2,3-二巯基-1-丙磺酸盐用于重金属中毒治疗
Med Toxicol Adverse Drug Exp. 1987 Sep-Oct;2(5):317-23. doi: 10.1007/BF03259951.
2
Protective effects of chelating agents against renal toxicity of gold sodium thiomalate in rats.螯合剂对大鼠硫代苹果酸金钠肾毒性的保护作用。
Arch Toxicol. 1991;65(7):532-6. doi: 10.1007/BF01973712.
本文引用的文献
1
The determination of gold in human liver by thermal neutron activation analysis.用热中子活化分析法测定人体肝脏中的金。
Phys Med Biol. 1963 Apr;8:43-50. doi: 10.1088/0031-9155/8/1/303.
2
[A novel metabolic cage for work with radionuclides].[一种用于放射性核素研究的新型代谢笼]
Strahlentherapie. 1966 Jun;130(2):314-6.
3
[Removal of internally deposited gold by penicillamine].[青霉胺对体内沉积金的清除作用]
Z Gesamte Exp Med Einschl Exp Chir. 1970 Aug 23;152(4):352-5.
4
[Gold therapy of rheumatic diseases I. Comparative studies in gold content of blood serum following application of sanocrysin and aurodetoxin].[风湿性疾病的金疗法I. 应用硫代苹果酸金钠和金毒素后血清金含量的比较研究]
Wien Klin Wochenschr. 1969 Dec 26;81(52):950-2.
5
Biliary plutonium excretion in the rat.大鼠胆汁中钚的排泄
Health Phys. 1972 Apr;22(4):369-72. doi: 10.1097/00004032-197204000-00008.
6
[Gold therapy in chronic joint rheumatism].[慢性关节风湿病的金疗法]
Internist (Berl). 1967 Jul;8(7):250-3.
7
[Radionuclide decontamination. "Prolonged" effect of DTPA].[放射性核素去污。二乙三胺五乙酸（DTPA）的“延长”效应]
Strahlentherapie. 1974 Mar;147(3):315-8.
8
[Gold therapy of chronic polyarthritis].[慢性多关节炎的金疗法]
Schweiz Med Wochenschr. 1977 Aug 20;107(33):1145-55.
9
Distribution and excretion of the mercury chelating agent sodium 2,3-dimercaptopropane-1-sulfonate in the rat.汞螯合剂2,3-二巯基丙磺酸钠在大鼠体内的分布与排泄
Arch Toxicol. 1978 Feb 14;39(4):289-98. doi: 10.1007/BF00296388.
10
Comparison of gold levels and distribution in guinea pig serum.豚鼠血清中黄金水平及分布的比较。
Arthritis Rheum. 1978 May;21(4):441-6. doi: 10.1002/art.1780210407.
Zotero 插件