哺乳动物和鸟类肝脏中葡萄糖激酶和己糖激酶的活性。
Activities of glucokinase and hexokinase in mammalian and avian livers.
作者信息
Stanley J C, Dohm G L, McManus B S, Newsholme E A
出版信息
Biochem J. 1984 Dec 1;224(2):667-71. doi: 10.1042/bj2240667.
Abstract
A radiochemical assay for glucokinase activity was developed for use in high-speed supernatants of liver. The maximum activities of glucokinase ranged from 0.4 to 3.8 mumol/min per g fresh wt. at 30 degrees C in some avian and mammalian livers, including pigeon, guinea pig and man, in which previous reports indicated zero activities. The reported maximum rates of hepatic glycogen synthesis in livers of rat and man in vivo are similar to the calculated glucokinase activities at 10mM-glucose; therefore glucokinase activity should not limit glycogen synthesis from glucose.
摘要
已开发出一种用于测定肝脏高速上清液中葡萄糖激酶活性的放射化学分析方法。在30摄氏度时，某些鸟类和哺乳动物肝脏（包括鸽子、豚鼠和人类，此前报道称其葡萄糖激酶活性为零）中葡萄糖激酶的最大活性范围为每克鲜重0.4至3.8微摩尔/分钟。据报道，大鼠和人类肝脏在体内肝糖原合成的最大速率与在10毫摩尔葡萄糖时计算出的葡萄糖激酶活性相似；因此，葡萄糖激酶活性不应限制由葡萄糖合成糖原。
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