Rabkin S W
Atherosclerosis. 1984 Nov;53(2):173-84. doi: 10.1016/0021-9150(84)90193-x.
The effect of cigarette smoking on other cardiovascular risk factors, serum lipids, body weight, blood pressure and blood sugar was assessed in a randomized control trial of reduction or cessation of cigarette smoking. In the intervention group (n = 107), reported cigarette use fell from 28.5 +/- 1.2 (+/- SEM) to 10.6 +/- 1.2 cigarettes/day and serum thiocyanate, a biochemical indicator of the extent of tobacco exposure, decreased -42.8 +/- 5.5 mumol/l (P less than 0.001). Compared to the control group, the intervention group showed significant (P less than 0.05) decreases in reported cigarette consumption and serum thiocyanate and significant (P less than 0.05) increases in body weight and skinfold thickness. Change in thiocyanate correlated significantly (P less than 0.05) and inversely with change in HDL-C, body weight and skinfold thickness, but not with change in LDL-C, triglycerides or blood pressure. These relationships remained significant even after adjusting in multivariate analysis, for initial measurements of these variables or regression to the mean. For those who quit smoking (n = 35) HDL-C increased 5.9 +/- 1.7 mg/dl (P less than 0.01). The usual inverse relationship between body weight and HDL-C does not exist with cessation of cigarette smoking. Thus, benefits of stopping cigarette smoking extend to favourable alterations in HDL-C and there are no adverse effects on blood pressure, fasting blood sugar, triglycerides or LDL-C.
在一项关于减少或戒烟的随机对照试验中，评估了吸烟对其他心血管危险因素、血脂、体重、血压和血糖的影响。在干预组（n = 107）中，报告的吸烟量从28.5±1.2（±SEM）支/天降至10.6±1.2支/天，血清硫氰酸盐（烟草暴露程度的生化指标）降低了-42.8±5.5μmol/l（P<0.001）。与对照组相比，干预组报告的吸烟量和血清硫氰酸盐显著降低（P<0.05），体重和皮褶厚度显著增加（P<0.05）。硫氰酸盐的变化与高密度脂蛋白胆固醇（HDL-C）、体重和皮褶厚度的变化显著负相关（P<0.05），但与低密度脂蛋白胆固醇（LDL-C）、甘油三酯或血压的变化无关。即使在多变量分析中对这些变量的初始测量值进行调整或回归均值后，这些关系仍然显著。对于戒烟者（n = 35），HDL-C升高了5.9±1.7mg/dl（P<0.01）。戒烟后，体重与HDL-C之间通常的负相关关系不存在。因此，戒烟的益处包括HDL-C的有利改变，且对血压、空腹血糖、甘油三酯或LDL-C没有不良影响。
