吸入氯乙烯后小鼠DNA中单链断裂的诱导

Induction of single-strand breaks in DNA of mice after inhalation of vinyl chloride.

作者信息

Walles S A, Holmberg B

出版信息

Cancer Lett. 1984 Nov;25(1):13-8. doi: 10.1016/s0304-3835(84)80020-8.

Abstract

Female mice were exposed to 500 ppm vinyl chloride (VC) for 6 h/day 5 days/week for 1-8 weeks. Groups of mice were killed at different times during this period. DNA damage, expressed as single-strand breaks (SSB), was studied in liver, kidneys, lungs, spleen and brain. The level of SSB increased in liver, kidneys, spleen and lungs with time of exposure and reached a plateau for kidneys and lungs after 80 and 120 h of exposure. In spleen there was only a slight increase in the SSB, and in brain no detectable increase was found.

摘要

雌性小鼠每周5天、每天6小时暴露于500 ppm氯乙烯（VC）中，持续1 - 8周。在此期间，在不同时间处死几组小鼠。研究了肝脏、肾脏、肺、脾脏和大脑中以单链断裂（SSB）表示的DNA损伤情况。肝脏、肾脏、脾脏和肺中的SSB水平随暴露时间增加，肾脏和肺在暴露80小时和120小时后达到平台期。脾脏中的SSB仅有轻微增加，大脑中未发现可检测到的增加。