Wiśniewska-Knypl J M, Klimczak J, Kołakowski J
Int Arch Occup Environ Health. 1980;46(3):241-9. doi: 10.1007/BF00380014.
The activity of microsomal cytochrome P-450 monooxygenase and ultrastructure of the liver have been studied in rats exposed dynamically to 50, 500, and 20,000 ppm of vinyl chloride (VC) over 10 months. After 1 and 3 months of exposure to 500 and 20,000 ppm of VC, the level of cytochrome P-450 was slightly lower than in the control animals and upon continuation of exposure it was restored to the original level accompanied by slight increase of activity of aniline p-hydroxylase. Liver enlargement, developed in the course of the exposure, was accompanied by ultrastructural alterations beginning in the 3rd month of exposure to all concentrations of VC. Development of hepatic alterations (hypertrophy of smooth and rough endoplasmic reticulum, swelling of mitochondria, accumulation of lipid droplets, focal cytoplasmic degradation) is discussed with regard to the activity of microsomal monooxygenase system in metabolizing VC to toxic metabolites.
对在10个月内动态暴露于50、500和20000 ppm氯乙烯（VC）的大鼠的微粒体细胞色素P - 450单加氧酶活性和肝脏超微结构进行了研究。在暴露于500和20000 ppm VC 1个月和3个月后，细胞色素P - 450水平略低于对照动物，继续暴露后恢复到原始水平，同时苯胺对羟基化酶活性略有增加。在暴露过程中出现的肝脏肿大，从暴露于所有浓度VC的第3个月开始伴有超微结构改变。结合微粒体单加氧酶系统将VC代谢为有毒代谢物的活性，讨论了肝脏改变（滑面和粗面内质网肥大、线粒体肿胀、脂滴积累、局灶性细胞质降解）的发展情况。
