Kuhn C M, Bartolome M
Dev Pharmacol Ther. 1984;7(6):384-97. doi: 10.1159/000457190.
This paper reports the effects of chronic postnatal methadone administration on basal hormone levels and on the endocrine response to methadone. Chronic postnatal methadone administration delayed normal developmental increases in serum T4 (decrease on day 5), corticosterone (CS) (days 15 and 20) and growth hormone (GH) (day 25). In addition, marked tolerance to methadone effects on GH, CS, thyroid-stimulating hormone (TSH) and prolactin (PRL) secretion developed during chronic postnatal administration, and effects on PRL and TSH secretion persisted after drug withdrawal.
本文报道了产后长期给予美沙酮对基础激素水平以及美沙酮内分泌反应的影响。产后长期给予美沙酮会延迟血清T4（第5天降低）、皮质酮（CS）（第15天和第20天）和生长激素（GH）（第25天）正常的发育性升高。此外，产后长期给药期间，机体对美沙酮影响GH、CS、促甲状腺激素（TSH）和催乳素（PRL）分泌产生了明显耐受性，且撤药后对PRL和TSH分泌的影响依然存在。
