大鼠对美沙酮内分泌反应的个体发生

Ontogeny of endocrine responses to methadone in rats.

作者信息

Kuhn C M, Bartolome M Q

出版信息

Life Sci. 1983 Apr 25;32(17):1967-74. doi: 10.1016/0024-3205(83)90048-6.

Abstract

The effects of methadone (METH) on serum levels of prolactin (PRL), growth hormone (GH), corticosterone (CS) and TSH were determined in developing rats. METH increased PRL, GH and CS and decreased TSH at all ages tested, but the time course and magnitude of these effects changed during ontogeny. METH effects on day 10 were lower in magnitude than those observed in adults. In 20 day old pups, METH effects on GH and CS were comparable to those of adults, but TSH effects were still blunted. METH effects on hormone secretion in both 10 and 20 day old pups lasted longer than those observed in adults. Naloxone blocked all hormonal responses in adults, but did not completely block METH effects on CS secretion in 10 day old pups.

摘要

在发育中的大鼠中测定了美沙酮（METH）对血清催乳素（PRL）、生长激素（GH）、皮质酮（CS）和促甲状腺激素（TSH）水平的影响。在所有测试年龄中，METH均使PRL、GH和CS升高，使TSH降低，但这些作用的时间进程和幅度在个体发育过程中发生了变化。在第10天，METH的作用幅度低于在成年大鼠中观察到的幅度。在20日龄幼崽中，METH对GH和CS的作用与成年大鼠相当，但对TSH的作用仍然减弱。METH对10日龄和20日龄幼崽激素分泌的作用持续时间比在成年大鼠中观察到的更长。纳洛酮阻断了成年大鼠的所有激素反应，但未完全阻断METH对10日龄幼崽CS分泌的作用。