[Pharmacological correction of disordered function of the myocardial contractile proteins].

The ability of some drugs to normalize the disturbed interaction of myocardial contractile proteins with ATP determined by superprecipitation of myocyte actomyosin was studied in experimental allergic and caffeine-adrenaline-induced injury to the rabbit myocardium. Ethimizole (2.5 mg/kg) appeared the most effective, while isolanide (0.005 mg/kg), contrykal (500 Units/kg), propranolol (1 mg/kg) and amidopyrine (10 mg/kg) were less effective. The action of prednisolone (5 mg/kg) appeared especially demonstrable in allergic myocardial injury.