Kivman G Ia, Guliaev A E, Sariev A K, Nadirova B A, Tulebaev E T
Farmakol Toksikol. 1984 Nov-Dec;47(6):71-4.
Experiments on white noninbred rats were made to study the binding by isolated organoids and distribution in liver cells of etazole, norsulfazole, sulfamonomethoxine and sulfalene. The latter drug was found to be absorbed by organoids to the greatest degree. Drug complexes with organoids were discovered to be capable of dissociating with a partial release of unbound drug. Intracellular distribution of sulfanilamides is marked by their accumulation primarily by the nuclei and to a lesser degree by the mitochondria and microsomes.
对白色非近交系大鼠进行实验，以研究乙唑、磺胺异恶唑、磺胺间甲氧嘧啶和磺胺林在离体类器官中的结合情况以及在肝细胞中的分布。发现后一种药物被类器官吸收的程度最大。已发现药物与类器官的复合物能够解离，未结合的药物会部分释放出来。磺胺类药物在细胞内的分布特点是主要在细胞核中积累，而在线粒体和微粒体中的积累程度较小。
