Makarov V A, Vasilenko Iu K, Suetina I V, Vaskanian V L, Lubiankina S V
Farmakol Toksikol. 1981 Jan-Feb;44(1):109-15.
Experiments on an isolated ileum of the rat with experimental hyperlipidemia have shown the decreased acetylation rate of sulfalen, sulfamonomethoxin and sulfapyridazine. The absorption rate of the free forms of sulfanilamides was increased (significantly for sulfalen and sulfapyridazine). Isadrin (1 . 10(-8) M) and cAMP (1 . 10(-5) M) introduced into the liquid exposed to the mucosa of the rat ileum raised the acetylation rate of sulfamonomethoxin by the ileic wall while anaprilin (1 . 10(-6) M) led to the reduction of both absorption and acetylation of this sulfanilamide. Addition of cAMP to the incubation mixture of mitochondria and microsomes increased the acetylation rate of sulfamonomethoxin.
对患有实验性高脂血症的大鼠离体回肠进行的实验表明，磺胺脒、磺胺间甲氧嘧啶和磺胺吡啶的乙酰化速率降低。磺胺类药物游离形式的吸收速率增加（磺胺脒和磺胺吡啶显著增加）。将异丙肾上腺素（1×10⁻⁸M）和环磷酸腺苷（1×10⁻⁵M）加入到与大鼠回肠黏膜接触的液体中，可提高回肠壁对磺胺间甲氧嘧啶的乙酰化速率，而心得安（1×10⁻⁶M）则导致该磺胺类药物的吸收和乙酰化均减少。向线粒体和微粒体的孵育混合物中添加环磷酸腺苷可提高磺胺间甲氧嘧啶的乙酰化速率。
