狼疮抗体与兔体内针对Sm和RNP抗原产生的抗体具有相同的特异性。
Identical specificity of lupus antibodies and antibodies elicited in rabbits against Sm and RNP antigens.
作者信息
Ishaq M, Ali R
出版信息
Immunol Commun. 1984;13(5):447-55. doi: 10.3109/08820138409033891.
PMID:6519680
Abstract
Rabbits immunized with purified Sm and RNP small nuclear ribonucleoproteins (snRNPs) produced precipitating and hemagglutinating antibodies against these antigens. These antibodies had immunological specificity identical to the naturally occurring SLE anti-Sm/RNP antibodies as demonstrated by immunoprecipitation results and studies involving the characterization of immunoaffinity purified antigens isolated from the rabbit immune and SLE anti-Sm/RNP IgG affinity columns.
摘要
用纯化的Sm和核糖核蛋白小核核糖核蛋白颗粒（snRNP）免疫的兔子产生了针对这些抗原的沉淀抗体和血凝抗体。如免疫沉淀结果以及涉及对从兔免疫和系统性红斑狼疮（SLE）抗Sm/RNP IgG亲和柱中分离出的免疫亲和纯化抗原进行特性鉴定的研究所表明，这些抗体具有与天然存在的SLE抗Sm/RNP抗体相同的免疫特异性。
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