Roth J A, Kaeberle M L, Hubbard R D
Immunopharmacology. 1984 Dec;8(3-4):121-8. doi: 10.1016/0162-3109(84)90015-8.
Thiabendazole was evaluated in two separate experiments for its ability to enhance the immune response in dexamethasone-treated or stressed cattle. In the first experiment the cattle received either no drug treatment (controls), dexamethasone intramuscularly (IM), or dexamethasone IM plus thiabendazole orally. All animals were inoculated with heat-killed Brucella abortus strain 19, equine ferritin, tetanus toxoid, and live Corynebacterium equi at the time dexamethasone therapy was initiated. Dexamethasone (0.04 mg/kg/day IM for 3 days) significantly (p less than 0.05) inhibited the lymphocyte blastogenic response to mitogens and the antibody response to ferritin and tetanus toxoid. Thiabendazole given orally (16 mg/kg/day) beginning 24 h prior to antigen and dexamethasone administration and continued for 6 days failed to prevent the dexamethasone-induced suppression of the lymphocyte blastogenic or antibody responses. In the second experiment 51 cattle were divided into a control group and a thiabendazole-treated group. The animals were stressed by weaning, injection of antigen (equine ferritin, tetanus toxoid, B. abortus strain 19 and killed bovine viral diarrhea virus) and castration of the bulls on the day that thiabendazole therapy was started. Thiabendazole administered orally for 5 days at a dosage of 20 mg/kg did not enhance the antibody response to any of the antigens, and was associated with a significantly lower antibody response to B. abortus.
在两项独立实验中评估了噻苯达唑增强地塞米松处理或应激牛免疫反应的能力。在第一项实验中，牛只接受以下处理：不进行药物治疗（对照组）、肌肉注射地塞米松（IM）、或肌肉注射地塞米松加口服噻苯达唑。在地塞米松治疗开始时，所有动物均接种了热灭活的布鲁氏菌流产菌株19、马铁蛋白、破伤风类毒素和活的马棒状杆菌。地塞米松（0.04mg/kg/天，肌肉注射，共3天）显著（p小于0.05）抑制了淋巴细胞对有丝分裂原的增殖反应以及对铁蛋白和破伤风类毒素的抗体反应。在抗原和地塞米松给药前24小时开始口服噻苯达唑（16mg/kg/天）并持续6天，未能预防地塞米松诱导的淋巴细胞增殖或抗体反应的抑制。在第二项实验中，51头牛被分为对照组和噻苯达唑治疗组。在开始噻苯达唑治疗当天，通过断奶、注射抗原（马铁蛋白、破伤风类毒素、布鲁氏菌流产菌株19和灭活的牛病毒性腹泻病毒）以及对公牛进行去势使动物处于应激状态。以20mg/kg的剂量口服噻苯达唑5天，并未增强对任何抗原的抗体反应，并且与对布鲁氏菌流产菌株的抗体反应显著降低有关。
