Kaeberle M L, Roth J A
Immunopharmacology. 1984 Dec;8(3-4):129-36. doi: 10.1016/0162-3109(84)90016-x.
Seven dosage levels of thiabendazole were evaluated for their ability to normalize lymphocyte or neutrophil function in dexamethasone-treated cattle. Dexamethasone administration (0.04 mg/kg intramuscularly daily for 3 days) significantly suppressed the lymphocyte blastogenic response to phytohemagglutinin, concanavalin A, and pokeweed mitogen. The lymphocyte blastogenic response to allogeneic lymphocytes was also suppressed in dexamethasone-treated cattle, but this effect was not statistically significant. Neutrophils from dexamethasone-treated cattle had a significantly enhanced ability to migrate under agarose, and significantly suppressed ability to reduce nitroblue tetrazolium, iodinate protein, and mediate antibody-dependent cell-mediated cytotoxicity. Thiabendazole when administered concurrently with dexamethasone in the dosage range from 1.0 to 25.0 mg/kg (orally) did significantly enhance lymphocyte blastogenic responsiveness to phytohemagglutinin, concanavalin A, pokeweed mitogen and allogeneic cells (in dexamethasone-treated cattle). This immunonormalizing effect was not observed at the 50 or 100 mg/kg dosage levels. Thiabendazole did not produce a consistent significant enhancement of any parameter of neutrophil function in dexamethasone-treated cattle.
评估了七种噻苯达唑剂量水平对接受地塞米松治疗的牛淋巴细胞或中性粒细胞功能恢复正常的能力。给予地塞米松（0.04mg/kg，每日肌肉注射，共3天）显著抑制了淋巴细胞对植物血凝素、刀豆球蛋白A和商陆有丝分裂原的增殖反应。接受地塞米松治疗的牛对同种异体淋巴细胞的淋巴细胞增殖反应也受到抑制，但这种效应在统计学上不显著。接受地塞米松治疗的牛的中性粒细胞在琼脂糖下迁移的能力显著增强，而还原硝基蓝四氮唑、碘化蛋白质和介导抗体依赖性细胞介导的细胞毒性的能力显著受到抑制。当噻苯达唑与地塞米松同时以1.0至25.0mg/kg（口服）的剂量范围给药时，确实显著增强了（接受地塞米松治疗的牛）淋巴细胞对植物血凝素、刀豆球蛋白A、商陆有丝分裂原和同种异体细胞的增殖反应性。在50或100mg/kg剂量水平未观察到这种免疫恢复正常的效果。噻苯达唑并未使接受地塞米松治疗的牛的中性粒细胞功能的任何参数产生一致的显著增强。
