Hale B, Megirian D, Pollard M J
J Appl Physiol Respir Environ Exerc Physiol. 1984 Nov;57(5):1564-8. doi: 10.1152/jappl.1984.57.5.1564.
We studied the effect of mild hypoxia (15% O2) and low ambient temperature (Ta = 15 degrees C) on the rat's sleep-waking pattern (SWP) and maximum-minimum core temperature (max-min Tb). Mild hypoxia at neutral Ta (29 degrees C) disrupted the SWP in the same way as low Ta during normoxia: both affected the pattern of frequency of state changes (P less than 0.01), not the pattern of epoch durations. Mild hypoxia and low Ta together caused a degree of disruption of the SWP which was the sum of each alone, i.e., additive. Although both mild hypoxia and low Ta significantly depressed max-min Tb, low Ta exerted a greater effect than mild hypoxia. Together they further depressed max-min Tb in an additive way. We conclude that mild hypoxia disrupts the rat's SWP independent of central thermoregulatory mechanisms at neutral Ta, that the effects of mild hypoxia and low Ta on the SWP are additive at the stimulus levels used, and that Ta, not inspired O2, determines Tb.
我们研究了轻度低氧（15%氧气）和低环境温度（Ta = 15摄氏度）对大鼠睡眠-觉醒模式（SWP）以及最高-最低核心体温（max-min Tb）的影响。在中性Ta（29摄氏度）下的轻度低氧与常氧时低Ta一样扰乱了SWP：二者均影响状态变化频率模式（P < 0.01），而非时段持续时间模式。轻度低氧和低Ta共同导致的SWP扰乱程度是二者单独作用之和，即具有相加性。虽然轻度低氧和低Ta均显著降低了max-min Tb，但低Ta的作用比轻度低氧更大。二者共同作用进一步以相加方式降低了max-min Tb。我们得出结论：在中性Ta时，轻度低氧独立于中枢体温调节机制扰乱大鼠的SWP，在所用刺激水平下，轻度低氧和低Ta对SWP的影响具有相加性，并且是Ta而非吸入的氧气决定Tb。
