Ryan A T, Ward D A, Megirian D
Exp Neurol. 1983 May;80(2):337-48. doi: 10.1016/0014-4886(83)90287-x.
Two groups, each consisting of six male rats, breathed 21% O2-4% CO2 or 10% O2-4% CO2, respectively, before and after carotid sinus nerve (CSN) transection. Polygraphic recording techniques served to monitor sleep and wakefulness. The effects of these gas mixtures on the sleep-waking pattern (SWP) were studied. The SWPs of the intact and CSN-transected rats breathing 21% O2-4% CO2 were no different from rats breathing air. While breathing 10% O2-4% CO2, the greatest alteration in the rat's SWP, compared with breathing 10% O2 devoid of CO2, was in the pattern of frequency of change of states, an effect unchanged by CSN transection. We conclude that CO2 added to air did not affect the rat's SWP. However, a hypoxic-CO2 gas mixture radically altered all parameters of the SWP, an effect which was centrally mediated.
两组，每组由六只雄性大鼠组成，分别在切断颈动脉窦神经（CSN）前后呼吸21% O₂ - 4% CO₂ 或10% O₂ - 4% CO₂ 。多导记录技术用于监测睡眠和清醒状态。研究了这些气体混合物对睡眠 - 觉醒模式（SWP）的影响。完整的和切断CSN的大鼠呼吸21% O₂ - 4% CO₂ 时的SWP与呼吸空气的大鼠没有差异。在呼吸10% O₂ - 4% CO₂ 时，与呼吸不含CO₂ 的10% O₂ 相比，大鼠SWP的最大变化在于状态变化频率模式，这种效应不受CSN切断的影响。我们得出结论，向空气中添加CO₂ 不会影响大鼠的SWP。然而，低氧 - CO₂ 气体混合物从根本上改变了SWP的所有参数，这种效应是由中枢介导的。
