Ito M, Hashimoto K, Yorder F W
J Cutan Pathol. 1984 Dec;11(6):513-21. doi: 10.1111/j.1600-0560.1984.tb00412.x.
Characteristic moniliform hairs of monilethrix were ultrastructurally examined. By scanning electron microscope, nodes and internodes were seen alternating on the affected hair; the nodes were normal in appearance and thickness, while the internodes were thin and showed ridges and flutes. By transmission electron microscope, the cross sections of the internodes revealed wrinkling of the hair cuticular cells and a reduced number of the cortical cells. Cross sections of the cortical cells per se showed a similar size and a normal keratin pattern in both nodes and internodes, compared with those of control hairs from normal individuals. From these findings, the internodes seemed to be the pathological portions of the moniliform hair, and such abnormal thinning of hair shaft might be caused by a periodical dysfunction of the hair matrix, especially in the hair cortex.
对毛发念珠状发特征性的串珠状毛发进行了超微结构检查。通过扫描电子显微镜观察，在患病毛发上可见结节和节间交替出现；结节外观和厚度正常，而节间较细，有嵴和沟。通过透射电子显微镜观察，节间的横截面显示毛表皮细胞起皱，皮质细胞数量减少。与正常个体的对照毛发相比，皮质细胞本身的横截面在结节和节间均显示出相似的大小和正常的角蛋白模式。从这些发现来看，节间似乎是串珠状毛发的病理部位，而这种毛干异常变细可能是由毛基质，尤其是毛皮质的周期性功能障碍引起的。
