Ito M, Hashimoto K, Sakamoto F, Sato Y, Voorhees J J
Department of Dermatology, Niigata University School of Medicine, Japan.
Arch Dermatol Res. 1988;280(5):308-18. doi: 10.1007/BF00440605.
Plucked scalp hairs and hair roots of pili annulati were examined to understand their pathogenesis. Stereoscopic examinations of hairs in transmitted light and/or reflected light and light microscopic surveys of the cross-sections of hairs confirmed that the cortical empty spaces appeared to be responsible to the unique dotted shiny appearance of the hairs seen by the unaided eyes under a refracted light. By transmission electron microscope, small vacuoles and dense bodies were observed in the cytoplasm of the differentiating cortical cells; subsequently, with increasing number of tono-filaments, an uneven distribution of free ribosomes occurred and abnormal spaces containing fine granular substances were formed in the cytoplasm of the cortical cells. Occasionally, extremely large cortical trichohyaline granules were found. In the keratinized hair, irregular empty spaces were present in the cortex of the abnormal hair segments. Histochemically, the keratinized cortex of the affected hairs always had more residual SH groups than the controls. Pili annulati may be a disorder of protein metabolism involving a partial dysfunction of cytoplasmic ribosomes, resulting in a lack of cortical keratin formation.
对拔取的斑秃头皮毛发和发根进行检查以了解其发病机制。在透射光和/或反射光下对毛发进行立体检查以及对毛发横截面进行光学显微镜观察证实，皮质中空区域似乎是导致在折射光下肉眼所见毛发独特的点状闪亮外观的原因。通过透射电子显微镜观察，在分化的皮质细胞的细胞质中观察到小液泡和致密体；随后，随着张力丝数量的增加，游离核糖体出现不均匀分布，并且在皮质细胞的细胞质中形成了含有细颗粒物质的异常空间。偶尔会发现极大的皮质毛透明颗粒。在角化毛发中，异常毛发段的皮质存在不规则的中空区域。组织化学分析表明，受累毛发的角化皮质总是比对照具有更多的残余巯基。斑秃可能是一种蛋白质代谢紊乱，涉及细胞质核糖体的部分功能障碍，导致皮质角蛋白形成不足。
