Dalvi R R, Robbins T J, Williams M K, Deoras D P, Donastorg F, Banks C
J Environ Sci Health B. 1984 Nov-Dec;19(8-9):703-12. doi: 10.1080/03601238409372458.
A single i.p. dose (120 mg/kg) of thiram given to male Sprague-Dawley rats caused a significant increase in the activity of SGOT and SGPT 24 hr post-treatment indicating liver damage. A considerable diminution in the serum cholinesterase activity was also noted in the treated rats as against the control animals. Additional evidence for thiram-induced liver toxicity is provided by the observation that there was approximately 50% inhibition of the activity of hepatic microsomal benzphetamine N-demethylase with a concomitant decrease in the concentration of cytochrome P-450, an important component of the mixed-function oxidase system. Although not significant, hepatic glutathione levels were also depleted by thiram, probably making the liver susceptible to toxic injury.
给雄性斯普拉格-道利大鼠腹腔注射单次剂量（120毫克/千克）的福美双，在治疗后24小时导致血清谷草转氨酶和谷丙转氨酶活性显著升高，表明肝脏受损。与对照动物相比，在接受治疗的大鼠中还观察到血清胆碱酯酶活性显著降低。福美双诱导肝毒性的其他证据是，观察到肝微粒体苄非他明N-脱甲基酶活性受到约50%的抑制，同时混合功能氧化酶系统的重要组成部分细胞色素P-450浓度降低。虽然不显著，但福美双也使肝脏谷胱甘肽水平降低，可能使肝脏易受毒性损伤。
