前列腺素D2（PGD2）——豚鼠离体心脏中一种强效的冠状动脉血管收缩剂。
Prostaglandin D2 (PGD2)--a potent coronary vasoconstrictor agent in the guinea pig isolated heart.
作者信息
Schrör K
出版信息
Naunyn Schmiedebergs Arch Pharmacol. 1978 Mar;302(1):61-2. doi: 10.1007/BF00586598.
The action of prostaglandin D2 (PGD2) on myocardial force of contraction (MFC) and coronary vascular resistance (CVR) was studied in the isovolumetrically perfused guinea pig heart at constant driving frequency (180 beats/min). PGD2 (2 . 10(-9) - 1 . 10(-6) M) produced a concentration-dependent increase in the CVR while the MFC remained unchanged. The ED50 (50% of maximum response) of the coronary vasomotor action amounted to 4.3 . 10(-8) M PGD2. The results give evidence for a potent coronary vasoconstrictor activity of PGD2.
在等容灌注的豚鼠心脏中，于恒定驱动频率（180次/分钟）下研究了前列腺素D2（PGD2）对心肌收缩力（MFC）和冠状血管阻力（CVR）的作用。PGD2（2×10⁻⁹ - 1×10⁻⁶ M）使CVR呈浓度依赖性增加，而MFC保持不变。冠状血管舒缩作用的半数有效剂量（ED50，最大反应的50%）相当于4.3×10⁻⁸ M PGD2。结果证明PGD2具有强大的冠状血管收缩活性。
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