Changes in functional ceruloplasmin concentrations of plasma and exudate and the effect of exogenous ceruloplasmin on the carrageenin-induced inflammation in rats.

Changes in functional ceruloplasmin (Cp) concentrations of plasma and exudate during acute and chronic inflammatory processes were studied in detail by measuring Cp oxidase activity in the carrageenin-induced inflammation in rats. In contrast with the plasma functional Cp level as an acute-phase reactant, the exudate functional Cp level was very low during the acute phase, increased in the chronic phase and reached a constant value which was only half value of the plasma functional Cp level. The locally injected Cp had no effect on the carrageenin-induced inflammation, suggesting that exogenous Cp has no anti-inflammatory effect on the inflamed rats eating normal diet.