Chio S L, Sin Y M
Department of Zoology, National University of Singapore.
Agents Actions. 1992 May;36(1-2):93-8. doi: 10.1007/BF01991235.
Carrageenan of different concentrations was injected into the 6-day-old air pouch in mice. It was found that 12 mg carrageenan caused a significant increase of plasma and exudate corticosterone levels at 24 h, while 1 and 3 mg carrageenan could only induce a significant increase of exudate corticosterone at 4 h. Elevation of corticosterone in both plasma and inflammatory exudate appeared to be correlated, suggesting that the exudate corticosterone was derived from the blood circulation. Injection of exogenous histamine and PGE2 into the air pouch induced a significant increase in exudate levels of corticosterone. However, plasma corticosterone increased significantly only after histamine administration, although a slight increase was observed in those injected with PGE2. These findings thus suggest that endogenous histamine and PGE2 which are released during carrageenan-induced acute inflammation, as shown in our previous work, might be responsible for the increase of corticosterone in both plasma and inflammatory exudate.
将不同浓度的角叉菜胶注射到6日龄小鼠的气囊肿中。结果发现，12毫克角叉菜胶在24小时时可使血浆和渗出液中皮质酮水平显著升高，而1毫克和3毫克角叉菜胶仅在4小时时能诱导渗出液中皮质酮显著升高。血浆和炎性渗出液中皮质酮的升高似乎相关，这表明渗出液中的皮质酮来源于血液循环。向气囊肿中注射外源性组胺和前列腺素E2可使渗出液中皮质酮水平显著升高。然而，仅在给予组胺后血浆皮质酮才显著升高，尽管注射前列腺素E2的小鼠也观察到轻微升高。因此，这些发现表明，如我们之前的研究所示，在角叉菜胶诱导的急性炎症过程中释放的内源性组胺和前列腺素E2可能是血浆和炎性渗出液中皮质酮升高的原因。
