Sharma R P, Kociba R J, Gehring P J
J Environ Pathol Toxicol Oncol. 1984 Jul;5(4-5):321-8.
Male white New Zealand rabbits were exposed orally to 0, 0.01, 0.1, 1 and 10 micrograms/kg/wk of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) for a period of 8 weeks. After 4 and 6 weeks of first TCDD administration, the rabbits were inoculated with a mixture of tetanus toxoid and Freund's adjuvant. TCDD exposure reduced the serum antitoxin titers, skin sensitivity to tuberculin, and the number of antibody producing cells in popliteal lymph nodes. At the end of the treatment period serum IgG levels were increased at the lowest dose of TCDD treatment while a marked depression was noticed at the highest dose level. An increase in the thymidine uptake by splenic lymphocytes in culture was noted at all levels of TCDD treatment whereas the response of these cells to phytomitogens was decreased at high levels of TCDD exposure. All different immunologic effects were not altered at the lowest TCDD treatment but both humoral and cell-mediated immune responses were depressed at the highest level of TCDD exposure.
将雄性新西兰白兔经口暴露于0、0.01、0.1、1和10微克/千克/周的2,3,7,8-四氯二苯并-对-二恶英（TCDD）中，持续8周。在首次给予TCDD 4周和6周后，给兔子接种破伤风类毒素和弗氏佐剂的混合物。TCDD暴露降低了血清抗毒素滴度、皮肤对结核菌素的敏感性以及腘窝淋巴结中产生抗体的细胞数量。在治疗期结束时，最低剂量TCDD治疗时血清IgG水平升高，而最高剂量水平时则出现明显下降。在所有TCDD治疗水平下，均观察到培养的脾淋巴细胞对胸腺嘧啶核苷的摄取增加，而在TCDD高暴露水平下，这些细胞对植物有丝分裂原的反应降低。最低剂量TCDD治疗时，所有不同的免疫效应均未改变，但在TCDD最高暴露水平下，体液免疫和细胞介导免疫反应均受到抑制。
