结晶过程中直接制备球形团聚的水杨酸晶体。

Direct preparation of spherically agglomerated salicylic acid crystals during crystallization.

作者信息

Kawashima Y, Okumura M, Takenaka H, Kojima A

出版信息

J Pharm Sci. 1984 Nov;73(11):1535-8. doi: 10.1002/jps.2600731110.

PMID:6520752

Abstract

Needle-like salicylic acid crystals were transformed into a spherically shaped dense form during crystallization by the spherical crystallization technique. Agitation of a mixture of ethanol-water-chloroform containing salicylic acid yielded spherically agglomerated salicylic acid crystals. The crystallinity of the agglomerated salicylic acid the amount of ethanol in the solvent mixture was decreased. The wettability of the agglomerated crystals increased when the amount of ethanol in the solvent mixture was decreased, and this enhanced the dissolution rate of the crystals. The remarkable improvements in the flow and packing of the agglomerated crystals enabled the direct compression of the crystals.

摘要

通过球形结晶技术，针状水杨酸晶体在结晶过程中转变为球形致密形态。对含有水杨酸的乙醇 - 水 - 氯仿混合物进行搅拌，得到球形团聚的水杨酸晶体。团聚水杨酸的结晶度随溶剂混合物中乙醇含量的降低而降低。当溶剂混合物中乙醇含量降低时，团聚晶体的润湿性增加，这提高了晶体的溶解速率。团聚晶体在流动性和堆积性方面的显著改善使得这些晶体能够直接压片。