Preparation of 7,8-dimethoxy-3,4-dihydroisoquinoline, facile route to 7,8-dioxygenated-3,4-dihydroisoquinolines.
作者信息
el-Fishawy A M, Slatkin D J, Knapp J E, Schiff P L
出版信息
J Pharm Sci. 1984 Nov;73(11):1639-40. doi: 10.1002/jps.2600731137.
PMID:6520770
Abstract
Oxidation of 7,8-dimethoxy-1,2,3,4-tetrahydroisoquinoline with potassium permanganate in acetone afforded 7,8-dimethoxy-3,4-dihydroisoquinoline as the primary product. Hence, oxidation of the appropriate secondary nonphenolic 7,8-dioxygenated tetrahydroisoquinoline alkaloid is thus a facile method for the generation of the corresponding imine. The imine is not easily prepared via the usual synthetic route involving ring closure of beta-phenethylamine derivatives.
摘要
相似文献
1
Preparation of 7,8-dimethoxy-3,4-dihydroisoquinoline, facile route to 7,8-dioxygenated-3,4-dihydroisoquinolines.
J Pharm Sci. 1984 Nov;73(11):1639-40. doi: 10.1002/jps.2600731137.
2
Synthesis of 8-Fluoro-3,4-dihydroisoquinoline and Its Transformation to 1,8-Disubstituted Tetrahydroisoquinolines.8-氟-3,4-二氢异喹啉的合成及其转化为 1,8-二取代四氢异喹啉。
Molecules. 2018 May 26;23(6):1280. doi: 10.3390/molecules23061280.
3
4
Further utilization of thiourea derivatives in the synthesis of new 1-substituted amino-3-methyl(or phenyl)-6.7-dimethoxy-3.4-dihydroisoquinolines. 5. The cyclodesulphurization of thio-compounds.硫脲衍生物在新型1-取代氨基-3-甲基（或苯基）-6,7-二甲氧基-3,4-二氢异喹啉合成中的进一步应用。5. 硫代化合物的环脱硫反应。
Pharmazie. 1973 Jun;28(6):364-6. doi: 10.1002/chin.197337274.
5
Solution-phase parallel synthesis of a diverse library of 1,2-dihydroisoquinolines.1,2-二氢异喹啉多样性文库的溶液相平行合成。
ACS Comb Sci. 2011 May 9;13(3):265-71. doi: 10.1021/co1000794. Epub 2011 Mar 16.
6
Complete assignments 1H and 13C NMR spectral data of four anabaseine derivatives.完成四种去甲烟碱衍生物的¹H和¹³C NMR光谱数据。
Magn Reson Chem. 2006 Dec;44(12):1131-4. doi: 10.1002/mrc.1911.
7
Synthesis, biological investigation and molecular docking study of N-malonyl-1,2-dihydroisoquinoline derivatives as brain specific and shelf-stable MAO inhibitors.N-丙二酰基-1,2-二氢异喹啉衍生物作为脑特异性且货架稳定的单胺氧化酶抑制剂的合成、生物学研究及分子对接研究
Eur J Med Chem. 2015 Mar 26;93:481-91. doi: 10.1016/j.ejmech.2015.02.039. Epub 2015 Feb 24.
8
1, 2-dihydroisoquinoline-N-acetic acid derivatives as new carriers for specific brain delivery I: synthesis and estimation of oxidation kinetics using multivariate calibration method.1,2 - 二氢异喹啉 - N - 乙酸衍生物作为特异性脑递送的新型载体I：使用多元校准法的合成及氧化动力学评估
Arch Pharm (Weinheim). 2003 Dec;336(12):573-84. doi: 10.1002/ardp.200300808.
9
[Rearrangement of 1-heteroaromatically substituted 1,2-dihydroisoquinolines. 17. Dihydroisoquinoline rearrangement].[1-杂芳基取代的1,2-二氢异喹啉的重排。17. 二氢异喹啉重排]
Arch Pharm (Weinheim). 1973 Aug;306(8):592-602.
10
[Dihydroisoquinoline-rearrangement. 8. Mechanism of rearrangement of tertiary 1,2-dihydroisoquinolines].[二氢异喹啉重排反应。8. 叔1,2 - 二氢异喹啉的重排机理]
Arch Pharm Ber Dtsch Pharm Ges. 1970 Jan;303(1):37-43. doi: 10.1002/ardp.19703030106.
Zotero 插件