Silverman E D, Smith R L, Schurman D J, Miller J J
J Rheumatol. 1984 Dec;11(6):798-803.
Inflammatory and noninflammatory juvenile synovial fluid (SF) samples were examined in vitro for their effect on cartilage. SF from 3 of 6 patients with pauciarticular juvenile arthritis (JA), 7 of 7 patients with polyarticular JA and 2 of 2 patients with ankylosing spondylitis had significantly increased proteoglycan (PG) releasing activity in 4 day cultures of living but not of freeze-killed cartilage. Noninflammatory SF did not cause increased PG release. Cartilage collagen content was not significantly altered by either inflammatory or noninflammatory SF. Our in vitro results showed PG releasing activity was present in inflammatory but not in normal juvenile SF.
对炎性和非炎性青少年滑液（SF）样本进行体外研究，观察其对软骨的影响。6例少关节型青少年关节炎（JA）患者中的3例、7例多关节型JA患者中的7例以及2例强直性脊柱炎患者的滑液，在活软骨而非冻存软骨的4天培养中，蛋白聚糖（PG）释放活性显著增加。非炎性滑液不会导致PG释放增加。炎性和非炎性滑液均未显著改变软骨胶原蛋白含量。我们的体外研究结果表明，PG释放活性存在于炎性青少年滑液中，而不存在于正常青少年滑液中。
