单侧肾小球原位DNA-抗DNA复合物形成
Unilateral glomerular DNA-anti-DNA complex formation in situ.
作者信息
O'Regan S, Turgeon C
出版信息
J Clin Lab Immunol. 1984 Oct;15(2):101-4.
PMID:6520858
Abstract
DNA has a high affinity for collagenous structures such as glomerular basement membrane. DNA was infused into the isolated left kidney in rats to determine whether this antigen though negatively charged would bind to glomerular structures. Mainly mesangial localization with minimal capillary localization was noted. Infusion of anti-DNA antibody after glomerular DNA binding allowed for formation of DNA-anti-DNA deposits in situ.
摘要
DNA对胶原结构如肾小球基底膜具有高度亲和力。将DNA注入大鼠的离体左肾，以确定这种带负电荷的抗原是否会与肾小球结构结合。主要观察到系膜定位，毛细血管定位极少。在肾小球结合DNA后注入抗DNA抗体，可在原位形成DNA-抗DNA沉积物。
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