Vakhliaev V D, Pomerantsev E V, Serova I V, Bogatyrev I V, Poltavskaia M G
Kardiologiia. 1984 Oct;24(10):60-3.
To study the hemodynamic and metabolic effects of isoptin, the drug was infused intravenously to 15 patients with acute transmural myocardial infarction at a dosage of 0.13-0.17 mg per kg bw. Along with the parameters of the central hemodynamics and the myocardial contractility of the left ventricle, using extraction coefficients the authors determined some parameters of myocardial metabolism. The drug was well tolerated by the patients, virtually did not affect the parameters of myocardial contractility, decreased the work of the heart at the expense of a significant reduction of the after-load and lowered manifestations of the ischemia of the intact myocardium (the coefficient of lactate extraction by the myocardium was found to elevate).
为研究异搏定的血流动力学和代谢效应，将该药以每千克体重0.13 - 0.17毫克的剂量静脉输注给15例急性透壁性心肌梗死患者。作者除测定中心血流动力学参数和左心室心肌收缩力外，还利用提取系数测定了心肌代谢的一些参数。患者对该药耐受性良好，实际上不影响心肌收缩力参数，通过显著降低后负荷来减少心脏做功，并减轻了存活心肌缺血的表现（发现心肌乳酸提取系数升高）。
