Molodan V I, Kopitsa N P, Dykun Ia V, Zarivchatskaia I T
Vrach Delo. 1990 Sep(9):6-8.
A study of 40 patients with acute myocardial infarction indicates that in those without circulatory insufficiency phynoptin did not reduce cardiac ejection but reduced postloads, energy expenditures and work of the left ventricle myocardium, favoured early stabilization of the cardiovascular system. In cases with cardiac insufficiency phynoptin reduced the contractile capacity of the left ventricle, stasis in the lesser circulation. Associated use of phynoptin and nitrates in acute myocardial infarction with circulatory insufficiency allowed to avoid depressive effect of phynoptin on myocardial contractility and to avoid progression of cardiac insufficiency.
一项针对40例急性心肌梗死患者的研究表明,在无循环功能不全的患者中,泛癸利酮并未降低心脏射血,但降低了后负荷、能量消耗及左心室心肌的作功,有利于心血管系统的早期稳定。在心脏功能不全的病例中,泛癸利酮降低了左心室的收缩能力,导致小循环淤血。在伴有循环功能不全的急性心肌梗死中联合使用泛癸利酮和硝酸盐,可避免泛癸利酮对心肌收缩力的抑制作用,并避免心脏功能不全的进展。