Khaltaev N G, Kazanskaia A I, Kuts G G, Verbitskaia A I, Bulin V A
Kardiologiia. 1984 Nov;24(11):15-20.
A comparative study of diet and drug correction of dyslipoproteinemias in individuals with stable hypercholesterolemia showed that following a month of diet treatment of groups selected for the therapy with probucol and ascorbic acid there was a clear-cut decrease in the level of plasma cholesterol. The administration of probucol in combination with the diet therapy decreased cholesterol by 33.6%, triglycerides by 32.8% and high density lipoprotein cholesterol (HDLC) by 19.7% as compared with the baseline values. Ascorbic acid showed virtually no effect on the lipid spectrum of the blood. Throughout the entire period of treatment, the patients in these groups showed a reduction in the body weight and blood pressure. In the group receiving only drug therapy, probucol use was associated with a statistically significant decrease in both total cholesterol and HDLC, with the HDLC/cholesterol ratio remaining almost unaltered while in the group receiving diet and probucol, the proportion of HDLC with regard to total cholesterol was elevated as against the initial values. The body weight in this group of patients remained actually unaltered.
一项针对稳定型高胆固醇血症患者血脂异常的饮食和药物纠正的比较研究表明，在用普罗布考和抗坏血酸进行治疗的选定组进行一个月的饮食治疗后，血浆胆固醇水平明显下降。与基线值相比，普罗布考与饮食疗法联合使用可使胆固醇降低33.6%，甘油三酯降低32.8%，高密度脂蛋白胆固醇（HDLC）降低19.7%。抗坏血酸对血液脂质谱几乎没有影响。在整个治疗期间，这些组的患者体重和血压均有所下降。在仅接受药物治疗的组中，使用普罗布考与总胆固醇和HDLC的统计学显著降低相关，HDLC/胆固醇比值几乎保持不变，而在接受饮食和普罗布考治疗的组中，HDLC占总胆固醇的比例相对于初始值有所升高。该组患者的体重实际上保持不变。
