Bauer J E, Covert S J
Lipids. 1984 Nov;19(11):844-50. doi: 10.1007/BF02534513.
The non-lipid portions of semi-synthetic diets appear to be important determinants of hypercholesterolemia and atherosclerosis in the rabbit. Serum and liver lipid concentrations were determined in rabbits which had been pair-fed various protein (casein or soy protein isolate) and carbohydrate (sucrose or dextrose) sources as part of low fat, low cholesterol, semi-synthetic diets. It was verified that casein-containing diets render rabbits hypercholesterolemic, while soy protein caused a degree of hypocholesterolemia. Additionally, sucrose, when fed in conjunction with casein, appears to augment this hypercholesterolemic effect. The distribution of total cholesterol among lipoprotein subclasses was increased in both the intermediate density lipoprotein (IDL) (1.006-1.019 g/ml) and low density lipoprotein (LDL) (1.019-1.063 g/ml) fractions and decreased in the high density lipoprotein (HDL) (1.063-1.21 g/ml) fraction when casein is fed. Soy protein feeding caused relatively more cholesterol to appear only in the IDL fraction when compared with commercial chow fed rabbits. Reasons for these differences may involve the saturation or suppression of endogenous lipoprotein hepatic receptors.
半合成饮食中的非脂质部分似乎是家兔高胆固醇血症和动脉粥样硬化的重要决定因素。在作为低脂、低胆固醇半合成饮食一部分，成对饲喂不同蛋白质（酪蛋白或大豆分离蛋白）和碳水化合物（蔗糖或葡萄糖）来源的家兔中，测定了血清和肝脏脂质浓度。已证实，含酪蛋白的饮食会使家兔出现高胆固醇血症，而大豆蛋白会导致一定程度的低胆固醇血症。此外，蔗糖与酪蛋白一起喂食时，似乎会增强这种高胆固醇血症效应。当喂食酪蛋白时，总胆固醇在脂蛋白亚类中的分布在中间密度脂蛋白（IDL）（1.006 - 1.019 g/ml）和低密度脂蛋白（LDL）（1.019 - 1.063 g/ml）组分中增加，而在高密度脂蛋白（HDL）（1.063 - 1.21 g/ml）组分中减少。与喂食商业饲料的家兔相比，喂食大豆蛋白时，相对更多的胆固醇仅出现在IDL组分中。这些差异的原因可能涉及内源性脂蛋白肝脏受体的饱和或抑制。
