[Binding of bis-(2-guanidoethyl)disulfide with DNA and polyriboadenylic acid in an aqueous solution. Study by ultrasonic velocimetry].

The interaction of DNA and poly(A) with bis-(2-guanidoethyl)disulfide (GED) which is the most simple model of arginine containing proteins has been investigated by means of ultrasonic velocimetry. It has been shown that the association of GED with nucleic acids proceeds by two stages. The stoichiometric relationships and association constants for each of these stages are estimated. A mechanism of the binding is proposed.