[双（2-胍基乙基）二硫化物对DNA中B型到A型转变的逆转]
[Reversal of B to A transition in DNA by bis-(20guanidoethyl)disulfide].
作者信息
Tselikova S V, Mandrugin A A, Lobachev V M, Ivanov V I
出版信息
Biofizika. 1982 Mar-Apr;27(2):322-4.
PMID:7074159
Abstract
Transition from B to A form of DNA in water/ethanol solutions is hindered by stoichiometric quantities of a bifunctional cation, bis-(2-guanidoethyl)disulfide (GED). Using the data on the shift and widening of the B--A transition curves in the presence of GED, a value of the order of 10 base pairs has been estimated for the cooperativity length of the B--A transition which agrees well with the values earlier obtained.
摘要
在水/乙醇溶液中，双功能阳离子双（2-胍基乙基）二硫化物（GED）的化学计量数量会阻碍DNA从B型向A型的转变。利用在GED存在下B - A转变曲线的位移和展宽数据，已估算出B - A转变的协同长度约为10个碱基对，这与早期获得的值非常吻合。
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