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Contribution of activated C3 to lymphocyte-mediated target lysis: complement-dependent cellular cytotoxicity.

作者信息

Yefenof E, Klein E, Yron I

出版信息

Mol Immunol. 1984 Dec;21(12):1211-4. doi: 10.1016/0161-5890(84)90012-9.

DOI:10.1016/0161-5890(84)90012-9
PMID:6521746
Abstract

Lysis of Raji cells by human lymphocytes was found to be enhanced if human serum was added to the assay. This was not due to the contribution of antibodies because hypogammaglobulinemic serum also augmented cytotoxicity. The results suggest that the mechanism of the enhancement was due to activation of C3 by the Raji cells. We assume that the cleavage products are deposited on cell surfaces in such a way that they contribute to contact between effector and target. Previous reports in two antibody-dependent cellular cytotoxicity systems provided other examples for the existence of this phenomenon.

摘要

相似文献

1
Contribution of activated C3 to lymphocyte-mediated target lysis: complement-dependent cellular cytotoxicity.
Mol Immunol. 1984 Dec;21(12):1211-4. doi: 10.1016/0161-5890(84)90012-9.
2
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J Exp Med. 1982 Sep 1;156(3):834-43. doi: 10.1084/jem.156.3.834.

引用本文的文献

1
Complement-dependent cellular cytotoxicity: lymphoblastoid lines that activate complement component 3 (C3) and express C3 receptors have increased sensitivity to lymphocyte-mediated lysis in the presence of fresh human serum.补体依赖的细胞毒性：激活补体成分3（C3）并表达C3受体的淋巴母细胞系在新鲜人血清存在的情况下，对淋巴细胞介导的裂解敏感性增加。
Proc Natl Acad Sci U S A. 1985 Aug;82(16):5470-4. doi: 10.1073/pnas.82.16.5470.
2
Biological characterization of a chimeric mouse-human IgM antibody directed against the 17-1A antigen.一种针对17-1A抗原的嵌合小鼠-人IgM抗体的生物学特性
Cancer Immunol Immunother. 1989;30(1):43-50. doi: 10.1007/BF01665029.