Beuche W, Friede R L
Neuropathol Appl Neurobiol. 1984 Sep-Oct;10(5):369-77. doi: 10.1111/j.1365-2990.1984.tb00367.x.
Bundles of axons enclosed by a single myelin sheath were found in the peripheral nerves of heterozygous obese C57BL-ob/+mice. Serial sections showed them to consist of two to forty naked axons encompassed by a common cuff of myelin formed by a single Schwann cell, with adjoining non-myelinated Schwann cells protruding from either side into the cuff. These structures are similar to those found in dystrophic mice, but there were no signs of dystrophy in the obese mice. It is suggested that the axon bundles result from a disturbance of early myelination, presumably of the phase of Schwann cell proliferation or of the communication between Schwann cells and axons.
在杂合子肥胖C57BL-ob/+小鼠的外周神经中发现了由单个髓鞘包裹的轴突束。连续切片显示，它们由两到四十根无髓鞘轴突组成，被单个施万细胞形成的共同髓鞘袖所包围，相邻的无髓鞘施万细胞从两侧伸入袖中。这些结构与在营养不良小鼠中发现的结构相似，但肥胖小鼠中没有营养不良的迹象。有人认为，轴突束是早期髓鞘形成紊乱的结果，可能是施万细胞增殖阶段或施万细胞与轴突之间通讯的紊乱。
