Nardoni A, Marchetti E, Geatti O, Di Piazza V, Rossi G
Minerva Med. 1984 Dec 15;75(47-48):2833-8.
The basal prolactinemia and the prolactinic reserve were investigated in 30 chronic alcoholics, during the alcohol withdrawal syndrome. In 80% of these patients, the prolactinic reserve was extremely low, while in 16,66% of them was normal or near the lowest limits, recognizing in the exaggerated dopaminergic central activity the responsible pathogenetic mechanism. The dopaminergic hyperactivity fits into a general context of the sympathetic-adrenergic hypertonia, which notoriously plays a primary pathogenetic role in the pathogenesis of the alcohol withdrawal syndrome. In 5 patients with an inhibited prolactin response, a normalization of the prolactin reserve was registered in a test (the same methoclopramide test) carried out after 2-3 months of abstinence from alcoholic beverages, as an evidence of the normalization of the central dopaminergic activity and of a dopaminergic hyperactivity during the alcohol withdrawal syndrome.
在酒精戒断综合征期间，对30名慢性酒精中毒者的基础催乳素血症和催乳素储备进行了研究。在这些患者中，80%的催乳素储备极低，而16.66%的患者催乳素储备正常或接近最低限度，认为多巴胺能中枢活动增强是其致病机制。多巴胺能亢进符合交感 - 肾上腺素能张力亢进的一般情况，众所周知，交感 - 肾上腺素能张力亢进在酒精戒断综合征的发病机制中起主要致病作用。在5例催乳素反应受抑制的患者中，在戒酒2 - 3个月后进行的一项检查（同甲氧氯普胺检查）中，催乳素储备恢复正常，这证明了中枢多巴胺能活动的正常化以及酒精戒断综合征期间多巴胺能亢进的存在。
