联合使用三种疗效欠佳的药物——洛莫司汀、长春新碱和博来霉素进行化疗，用于治疗III期黑色素瘤。
Combination chemotherapy with three marginally effective agents, CCNU, vincristine, and bleomycin, in the treatment of stage III melanoma.
作者信息
De Wasch G, Bernheim J, Michel J, Lejeune F, Kenis Y
出版信息
Cancer Treat Rep. 1976 Sep;60(9):1273-6.
Forty-two patients with stage III melanoma were treated with a combination of CCNU, bleomycin, and vincristine. Seventeen of 35 evaluable patients achieved an objective response (48.5%) including five patients with CRs. The median duration of response was 4 months (range, 1-18 months). The responders had a median survival of 278 days (range, 78-1100 days) and the nonresponders had a median survival of 168 days (range 34-619 days). The toxicity off the combination was within an acceptable range with no toxic deaths.
42例III期黑色素瘤患者接受了洛莫司汀、博来霉素和长春新碱联合治疗。35例可评估患者中有17例获得客观缓解（48.5%），其中5例完全缓解。缓解的中位持续时间为4个月（范围1 - 18个月）。缓解者的中位生存期为278天（范围78 - 1100天），未缓解者的中位生存期为168天（范围34 - 619天）。该联合治疗的毒性在可接受范围内，无毒性死亡。
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