Rothwell N J, Stock M J, Wyllie M G
Pflugers Arch. 1984 Nov;402(3):325-9. doi: 10.1007/BF00585518.
The effects of histamine antagonists on noradrenaline-stimulated metabolic rate, tissue blood flow (estimated from the distribution of radiolabelled microspheres) and brown adipose tissue (BAT) oxygen extraction were studied in male anaesthetised rats. Injection of cimetidine (H2-receptor antagonist), reduced the noradrenaline-stimulation of metabolic rate and the increase in blood flow to BAT, but did not affect blood flow to white adipose tissue, skin, leg muscle, kidney, brain, or testes. Following noradrenaline, in vivo oxygen consumption of BAT, estimated from blood flow and oxygen extraction was depressed to 31% of control values by treatment with cimetidine, blood pressure was unaffected. Injection of the histamine (H1-receptor) antagonist, mepyramine, did not affect tissue blood flow or metabolic rate. In conscious animals, cimetidine did not affect resting oxygen consumption, but depressed the thermogenic responses to noradrenaline. These data suggest that the stimulation of BAT blood flow and thermogenesis by noradrenaline may be mediated in part by histamine acting on an H2-type receptor.
在雄性麻醉大鼠中研究了组胺拮抗剂对去甲肾上腺素刺激的代谢率、组织血流量（根据放射性标记微球的分布估算）和棕色脂肪组织（BAT）氧摄取的影响。注射西咪替丁（H2受体拮抗剂）可降低去甲肾上腺素对代谢率的刺激以及BAT血流量的增加，但不影响白色脂肪组织、皮肤、腿部肌肉、肾脏、大脑或睾丸的血流量。注射去甲肾上腺素后，通过血流量和氧摄取估算的BAT体内氧消耗量经西咪替丁处理后降至对照值的31%，血压未受影响。注射组胺（H1受体）拮抗剂美吡拉敏不影响组织血流量或代谢率。在清醒动物中，西咪替丁不影响静息氧消耗量，但会抑制对去甲肾上腺素的产热反应。这些数据表明，去甲肾上腺素对BAT血流量和产热的刺激可能部分由组胺作用于H2型受体介导。
