Albrechtsen M, Bock E, Nørgaard-Pedersen B
Prenat Diagn. 1984 Nov-Dec;4(6):405-10. doi: 10.1002/pd.1970040603.
The glial fibrillary acidic protein (GFAP) is the subunit protein of intermediate filaments in astrocytes and closely related cell types. By means of an enzyme immunoassay we have determined the concentration of GFAP in amniotic fluids from normal pregnancies and from pregnancies complicated by various fetal malformations. The group of 20 cases of fetal anencephaly had a significantly higher mean amniotic fluid GFAP concentration (115 micrograms/l +/- 133.6 (S.D.), range 6-378 micrograms/l) than the control group of 117 normal pregnancies (13 micrograms/l +/- 5.5 (S.D.), range 0-31 micrograms/l), (P less than 0.001). Two cases of fetal encephalocele likewise had very high amniotic fluid GFAP concentrations. None of the other cases of fetal malformations investigated, including 12 cases of spina bifida, had increased amniotic fluid GFAP concentrations. We conclude that determination of the amniotic fluid GFAP concentration may give additional information in the prenatal diagnosis of fetal nervous system malformations.
胶质纤维酸性蛋白（GFAP）是星形胶质细胞及密切相关细胞类型中间丝的亚基蛋白。我们通过酶免疫测定法测定了正常妊娠以及并发各种胎儿畸形妊娠的羊水样本中GFAP的浓度。20例胎儿无脑儿组羊水GFAP平均浓度（115微克/升±133.6（标准差），范围6 - 378微克/升）显著高于117例正常妊娠对照组（13微克/升±5.5（标准差），范围0 - 31微克/升），（P<0.001）。2例胎儿脑膨出的羊水GFAP浓度同样非常高。包括12例脊柱裂在内的其他所研究胎儿畸形病例，其羊水GFAP浓度均未升高。我们得出结论，测定羊水GFAP浓度可能为胎儿神经系统畸形的产前诊断提供更多信息。
