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[硝基呋喃对球菌细菌膜器的作用]

[The effect of nitrofurans on the membrane apparatus of coccal bacteria].

作者信息

Kutsmako R T, Kuliash Iu V, Rudzit E A, Ermachenko V A, Simakova I M

出版信息

Prikl Biokhim Mikrobiol. 1984 Nov-Dec;20(6):798-803.

PMID:6522358
Abstract

Secondary membrane effects on the membrane apparatus of coccus bacteria were being studied. Cultivation of Micrococcus lysodeikticus and Staphylococcus aureus cells on subbacteriostatic concentrations of nitrofurans results in a lower biosynthesis of many membrane proteins, as well as in inhibiting the activity of respiratory enzymes, i. e. the specific concentration of cytochromes and specific activity of NADH-, malate-, lactate oxidases and some reductases drop. Some cytological changes were revealed, when cells were grown on solafur, furazolidone, and furacriline.

摘要

正在研究球菌细菌的膜装置的继发性膜效应。在低于抑菌浓度的硝基呋喃上培养溶壁微球菌和金黄色葡萄球菌细胞,会导致许多膜蛋白的生物合成降低,以及抑制呼吸酶的活性,即细胞色素的特定浓度以及NADH、苹果酸、乳酸氧化酶和一些还原酶的比活性下降。当细胞在索拉呋、呋喃唑酮和呋吖啶上生长时,发现了一些细胞学变化。

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