Kusumoto Y, Goto M, Tajima H, Nakata K, Furukawa R, Satoh A, Kawahara K, Ishii N, Munehisa T, Koji T
Radioisotopes. 1984 Oct;33(10):686-90. doi: 10.3769/radioisotopes.33.10_686.
To determine the diagnostic value of anti-HBc IgM in acute viral hepatitis or chronic liver disease B, Anti-HBc IgM was measured by a RIA and an ELISA in 32 patients with acute hepatitis (4 with type A, 15 with type B and 13 with type non A non B), 18 patients with chronic hepatitis and 19 patients with liver cirrhosis. In acute hepatitis B, anti-HBc IgM (both RIA and ELISA) was positive in 14(93%) of 15 patients and its cut-off index value was very high. However, anti-HBc IgM was always negative in one patient with typical course of type B. In 1 of 4 patients with acute hepatitis A and 2 of 13 with non A non B, anti-HBc IgM (RIA and/or ELISA) was positive. These 3 patients were positive for anti-HBs at the onset of disease, so we could not made the diagnosis of acute hepatitis B. Anti-HBc IgM was positive in 21(51%) of 37 patients with HBsAg-positive chronic liver disease by RIA and in 11 (30%) by ELISA, and its cut-off index value was relatively low. These results suggest that when adequate cut-off index value is established, anti-HBc analysis is useful for differentiating recent and current infections from remote infections.
为确定抗 - HBc IgM在急性病毒性肝炎或慢性乙型肝病中的诊断价值，采用放射免疫分析法（RIA）和酶联免疫吸附测定法（ELISA）检测了32例急性肝炎患者（4例甲型肝炎、15例乙型肝炎和13例非甲非乙型肝炎）、18例慢性肝炎患者和19例肝硬化患者的抗 - HBc IgM。在急性乙型肝炎中，15例患者中有14例（93%）抗 - HBc IgM（RIA和ELISA法）呈阳性，其临界指数值非常高。然而，1例典型病程的乙型肝炎患者抗 - HBc IgM始终为阴性。在4例急性甲型肝炎患者中有1例，13例非甲非乙型肝炎患者中有2例抗 - HBc IgM（RIA和/或ELISA法）呈阳性。这3例患者在疾病发作时抗 - HBs呈阳性，因此我们无法诊断为急性乙型肝炎。在37例HBsAg阳性慢性肝病患者中，21例（51%）采用RIA法检测抗 - HBc IgM呈阳性，11例（30%）采用ELISA法检测呈阳性，其临界指数值相对较低。这些结果表明，当建立适当的临界指数值时，抗 - HBc分析有助于区分近期和当前感染与既往感染。
