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溶血性自身抗-Vel的第三个例子。

A third example of haemolytic auto-anti-Vel.

作者信息

Ferrer Z, Cornwall S, Berger R, Moore B P, Chung A, Strong J, Eggertson V

出版信息

Rev Fr Transfus Immunohematol. 1984 Oct;27(5):639-44. doi: 10.1016/s0338-4535(84)80085-9.

DOI:10.1016/s0338-4535(84)80085-9
PMID:6522937
Abstract

A non-transfused, 43 year old Caucasian female presented with acute haemolytic anaemia and splenomegaly. Sections of bone marrow showed erythroid hyperplasia. The patient's red blood cells gave a negative reaction with polyspecific antiglobulin serum, but a positive reaction with specific anti-IgM. A heat eluate prepared from her red cells showed anti-Vel specificity. Her serum agglutinated only Vel-positive cells including her own. All papain pre-treated red cells including her own and Vel-negative cells were completely haemolysed at 37 degrees C. The percentage of haemolysis of Vel-positive cells was greater than that of Vel-negative cells.

摘要

一名43岁未输血的白种女性出现急性溶血性贫血和脾肿大。骨髓切片显示红系增生。患者的红细胞与多特异性抗球蛋白血清反应阴性,但与特异性抗IgM反应阳性。从她的红细胞制备的热洗脱液显示具有抗Vel特异性。她的血清仅凝集包括她自己在内的Vel阳性细胞。所有经木瓜蛋白酶预处理的红细胞,包括她自己的和Vel阴性细胞,在37℃时完全溶血。Vel阳性细胞的溶血百分比高于Vel阴性细胞。

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