Filiaci F, Di Filippo S, Lucarelli N, Zambetti G
Rhinology. 1984 Dec;22(4):261-8.
The authors refer results of a 3-year study carried out on ten patients suffering from hay fever, diagnosed by means of skin tests, specific nasal provocation and serum RAST who underwent specific local immunotherapy consisting of application of an aqueous allergenic extract, the initial level of which was based on threshold values resulting from the nasal provocation test. The two-monthly check ups were based on the evaluation of mucociliary clearance, anterior rhinorheomanometry, specific nasal provocation and the test of Maunsell for blocking antibodies, as well as on the drawing up of a daily symptomatological diary for each single patient. The results were extremely interesting: subsidence of symptoms during the pollinating season, an increase in the number of blocking serum antibodies and of threshold values relative to specific nasal provocation. Conductance and mucociliary clearance, which were both decidedly pathological before beginning the local immunotherapy, slowly returned to the norm. The authors, furthermore, refer that the use of disodium cromoglycate during the first months of specific local immunotherapy which allows them to reach doses 5-7 times greater than those obtainable with the above mentioned form of treatment, offers uncertain advantages as far as local and above all general immunity is concerned and this alone does not justify the use of nasal applications in the treatment of bronchial asthma of allergic origin.
作者提到了一项针对10名花粉热患者进行的为期3年的研究结果。这些患者通过皮肤试验、特异性鼻激发试验和血清RAST进行诊断，接受了特异性局部免疫疗法，即应用水性变应原提取物，其初始剂量基于鼻激发试验得出的阈值。每两个月的检查基于对黏液纤毛清除功能、前鼻测压法、特异性鼻激发试验以及用于检测封闭抗体的莫恩塞尔试验的评估，同时还为每位患者制定每日症状日记。结果非常有趣：在授粉季节症状减轻，封闭血清抗体数量增加，特异性鼻激发试验的阈值升高。在开始局部免疫疗法之前均明显异常的鼻通气和黏液纤毛清除功能，缓慢恢复到正常水平。此外，作者指出，在特异性局部免疫疗法的最初几个月使用色甘酸钠，使他们能够达到比上述治疗形式所能获得的剂量高5至7倍的剂量，但就局部尤其是全身免疫而言，其优势并不确定，仅凭这一点并不足以证明在治疗过敏性起源的支气管哮喘时使用鼻用制剂是合理的。
