Crifó S, De Seta E, Lucarelli N, Masieri S
Allergol Immunopathol (Madr). 1980 Jan-Feb;8(1):1-6.
The preliminary results are presented of a study carried out on 23 subjects with nasal allergy to graminacea, 10 of whom were used as a control group to verify the clinical advantages and the possible side effects of a specific local immunotherapy carried out in spray form using progressively increasing doses of allergen in aqueous solution. From a clinical point of view, on the grounds of the score in the clinical diary, we were able to show that during the preseasonal stage only 5 patients treated with the allergen were free of symptoms as were the controls, whereas during the critical phase they were all free of symptoms in contrast to the crisis presented in the control group. The increase in the threshold of nasal provocation and in the serum level of blocking antibodies, revealed in the majority of the subjects affected by pollinosis and treated locally with the allergen, are to be considered fundamental to the clinical advantage obtained. In agreement with what has already been revealed after specific nasal provocation, local treatment with allergens caused in a majority of cases a slight increase in the time of mucociliar clearance, a phenomenon which must be taken carefully into consideration in as much as it could eventually represent an adverse side effect which needs an adequate countermeasure.
本文呈现了一项针对23名对禾本科植物过敏的鼻腔过敏患者的初步研究结果。其中10名患者作为对照组，以验证采用喷雾形式进行的特定局部免疫疗法的临床优势及可能的副作用，该疗法使用逐次增加剂量的过敏原水溶液。从临床角度来看，根据临床日记中的评分，我们发现，在季前阶段，只有5名接受过敏原治疗的患者无症状，与对照组情况相同；而在关键阶段，接受治疗的患者均无症状，对照组则出现了症状发作。大多数花粉症患者接受局部过敏原治疗后，鼻激发阈值升高以及血清中阻断抗体水平升高，这些被认为是取得临床优势的关键因素。与特定鼻激发试验后已揭示的情况一致，在大多数病例中，过敏原局部治疗导致黏液纤毛清除时间略有增加，鉴于这最终可能代表一种需要适当应对措施的不良副作用，这一现象必须予以谨慎考虑。
