斯里兰卡人和印度人中的人类白细胞抗原与丝虫病

HLA and filariasis in Sri Lankans and Indians.

作者信息

Chan S H, Dissanayake S, Mak J W, Ismail M M, Wee G B, Srinivasan N, Soo B H, Zaman V

出版信息

Southeast Asian J Trop Med Public Health. 1984 Sep;15(3):281-6.

Abstract

Similar HLA association was found in patients with elephantiasis in Sri Lankans and Southern Indians. HLA-B15 was observed in 13/44 (30%) Sri Lankan patients with elephantiasis compared to 1/27 (4%) Sri Lankan controls (p = .0058; RR = 10.9) and in 5/8 (28%) Southern Indian elephantiasis compared to 10/101 (10%) Southern Indian controls (p = 0.04; RR = 3.5). In combining the data, the significance of the difference of the frequency of B15 between patients with elephantiasis and controls was even more marked (p = 0.00045; corrected p = 0.012; RR = 4.4).

摘要

在斯里兰卡人和南印度人的象皮肿患者中发现了类似的HLA关联。在44名患有象皮肿的斯里兰卡患者中，有13名（30%）观察到HLA - B15，而在27名斯里兰卡对照者中只有1名（4%）观察到（p = 0.0058；相对危险度 = 10.9）；在8名患有象皮肿的南印度患者中有5名（28%）观察到，而在101名南印度对照者中有10名（10%）观察到（p = 0.04；相对危险度 = 3.5）。综合这些数据，象皮肿患者与对照者之间B15频率差异的显著性更加明显（p = 0.00045；校正p = 0.012；相对危险度 = 4.4）。