曼尼菲青霉聚糖结合蛋白多态性与坦桑尼亚东北部两个社区班氏丝虫感染的关系。
Association between mannose-binding lectin polymorphisms and Wuchereria bancrofti infection in two communities in North-Eastern Tanzania.
机构信息
Section of Health Services Research, Department of Public Health, University of Copenhagen, Denmark.
出版信息
Am J Trop Med Hyg. 2010 Jan;82(1):115-20. doi: 10.4269/ajtmh.2010.09-0342.
Abstract
The association between selected mannose-binding lectin (MBL) genotype polymorphisms and Wuchereria bancrofti infection status was assessed among individuals whose infection status had been monitored for three decades. Blood samples were collected in 2006 and examined for polymorphisms in the mbl-2 gene and for W. bancrofti-specific circulating filarial antigen (CFA) status. Logistic regression analysis showed a significant association between MBL genotype and CFA status, with low-expression MBL genotype individuals being almost three times more likely to be CFA positive than high-expression MBL genotype individuals (odds ratio [OR] = 2.90). When individuals' filarial infection (microfilaria) status in 1975 was included in the analyses, the gain of new infections between the two examination points was almost 10 times higher among individuals with low than among those with high MBL expression genotype (OR = 9.51). The susceptibility to W. bancrofti infection thus appears to be significantly affected by the MBL expression genotype of the host.
摘要
在对感染状况进行了三十年监测的人群中，评估了特定甘露糖结合凝集素（MBL）基因型多态性与班氏丝虫感染状况之间的关联。于 2006 年采集血样，检测 mbl-2 基因的多态性以及班氏丝虫特异性循环丝虫抗原（CFA）状况。逻辑回归分析显示 MBL 基因型与 CFA 状况之间存在显著关联，低表达 MBL 基因型个体 CFA 阳性的可能性几乎是高表达 MBL 基因型个体的三倍（比值比[OR] = 2.90）。当将个体在 1975 年的丝虫感染（微丝蚴）状况纳入分析时，在两个检测点之间获得新感染的个体中，低 MBL 表达基因型个体的感染率几乎比高 MBL 表达基因型个体高 10 倍（OR = 9.51）。因此，宿主的 MBL 表达基因型明显影响对班氏丝虫的易感性。
相似文献
1
Association between mannose-binding lectin polymorphisms and Wuchereria bancrofti infection in two communities in North-Eastern Tanzania.曼尼菲青霉聚糖结合蛋白多态性与坦桑尼亚东北部两个社区班氏丝虫感染的关系。
Am J Trop Med Hyg. 2010 Jan;82(1):115-20. doi: 10.4269/ajtmh.2010.09-0342.
2
A polymerase chain reaction assay for detection of the parasite Wuchereria bancrofti in human blood samples.一种用于检测人类血液样本中寄生虫班氏吴策线虫的聚合酶链反应检测法。
Am J Trop Med Hyg. 1996 Apr;54(4):357-63. doi: 10.4269/ajtmh.1996.54.357.
3
Co-infection with subclinical HIV and Wuchereria bancrofti, and the role of malaria and hookworms, in adult Tanzanians: infection intensities, CD4/CD8 counts and cytokine responses.坦桑尼亚成年人中亚临床HIV与班氏吴策线虫合并感染以及疟疾和钩虫的作用：感染强度、CD4/CD8计数及细胞因子反应
Trans R Soc Trop Med Hyg. 2007 Jun;101(6):602-12. doi: 10.1016/j.trstmh.2007.02.009. Epub 2007 Mar 28.
4
Genetic polymorphisms in molecules of innate immunity and susceptibility to infection with Wuchereria bancrofti in South India.印度南部先天性免疫分子的基因多态性与班氏吴策线虫感染易感性
Genes Immun. 2001 Aug;2(5):248-53. doi: 10.1038/sj.gene.6363767.
5
Development of a quantitative, competitive polymerase chain reaction--enzyme-linked immunosorbent assay for the detection of Wuchereria bancrofti DNA.用于检测班氏吴策线虫DNA的定量竞争性聚合酶链反应-酶联免疫吸附测定法的开发。
Parasitol Res. 1999 Mar;85(3):176-83. doi: 10.1007/s004360050531.
6
A recombinant clone of Wuchereria bancrofti with DNA specificity for human lymphatic filarial parasites.一种对人类淋巴丝虫寄生虫具有DNA特异性的班氏吴策线虫重组克隆。
Mol Biochem Parasitol. 1991 Jul;47(1):63-71. doi: 10.1016/0166-6851(91)90148-y.
7
Dynamics of antigenemia and transmission intensity of Wuchereria bancrofti following cessation of mass drug administration in a formerly highly endemic region of Mali.在马里一个曾经高度流行的地区停止大规模药物给药后，班氏吴策线虫抗原血症动态及传播强度
Parasit Vectors. 2016 Dec 3;9(1):628. doi: 10.1186/s13071-016-1911-9.
8
Positivity of Antigen Tests Used for Diagnosis of Lymphatic Filariasis in Individuals Without Wuchereria bancrofti Infection But with High Loa loa Microfilaremia.在未感染班氏吴策线虫但罗阿丝虫微丝蚴血症水平高的个体中，用于诊断淋巴丝虫病的抗原检测的阳性情况。
Am J Trop Med Hyg. 2016 Dec 7;95(6):1417-1423. doi: 10.4269/ajtmh.16-0547. Epub 2016 Oct 10.
9
Absence of association between mannose-binding lectin gene polymorphisms and HIV-1 infection in a Colombian population.哥伦比亚人群中甘露糖结合凝集素基因多态性与HIV-1感染之间无关联。
Immunogenetics. 2003 Apr;55(1):49-52. doi: 10.1007/s00251-003-0550-4. Epub 2003 Mar 25.
10
Wuchereria bancrofti-infected individuals harbor distinct IL-10-producing regulatory B and T cell subsets which are affected by anti-filarial treatment.班氏丝虫感染者体内存在具有独特特征的产生白细胞介素-10 的调节性 B 和 T 细胞亚群，这些亚群受抗丝虫治疗的影响。
PLoS Negl Trop Dis. 2019 May 23;13(5):e0007436. doi: 10.1371/journal.pntd.0007436. eCollection 2019 May.
引用本文的文献
1
Prevalence of elephantiasis, an overlooked disease in Southern Africa: a comprehensive review.象皮肿在南部非洲的患病率：一项全面综述，一种被忽视的疾病
J Venom Anim Toxins Incl Trop Dis. 2024 Oct 14;30:e20240007. doi: 10.1590/1678-9199-JVATITD-2024-0007. eCollection 2024.
2
Duplication mutation in CHIT1 gene is associated with poor response to medical therapy in patients affected with filarial chyluria.几丁质酶1（CHIT1）基因的重复突变与丝虫性乳糜尿患者药物治疗反应不佳相关。
Bioinformation. 2020 Sep 30;16(9):688-694. doi: 10.6026/97320630016688. eCollection 2020.
3
Genetic association of MBL-2 gene polymorphisms with Filarial chyluria.甘露聚糖结合凝集素2（MBL-2）基因多态性与丝虫性乳糜尿的遗传关联
Bioinformation. 2019 Dec 10;15(11):806-811. doi: 10.6026/97320630015806. eCollection 2019.
4
The Genetic Polymorphisms of 24 Base Pair Duplication and Point G102S of Human Chitotriosidase to Bancroftian Filariasis at the Thai⁻Myanmar Border.泰国-缅甸边境地区人类几丁质酶24碱基对重复和G102S点突变的基因多态性与班氏丝虫病的关系
Pathogens. 2019 Mar 25;8(1):41. doi: 10.3390/pathogens8010041.
5
Genetic and Phenotypic Screening of Mannose-Binding Lectin in Relation to Risk of Recurrent Vulvovaginal Infections in Women of North India: A Prospective Cohort Study.印度北部女性中甘露糖结合凝集素与复发性外阴阴道感染风险相关的基因和表型筛查：一项前瞻性队列研究
Front Microbiol. 2017 Jan 31;8:75. doi: 10.3389/fmicb.2017.00075. eCollection 2017.
6
A comprehensive in silico analysis of non-synonymous and regulatory SNPs of human MBL2 gene.人类MBL2基因非同义单核苷酸多态性和调控单核苷酸多态性的全面计算机模拟分析。
Springerplus. 2016 Jun 21;5(1):811. doi: 10.1186/s40064-016-2543-4. eCollection 2016.
7
Particularities of allergy in the Tropics.热带地区过敏的特殊性。
World Allergy Organ J. 2016 Jun 27;9:20. doi: 10.1186/s40413-016-0110-7. eCollection 2016.
8
MBL-2 polymorphisms (codon 54 and Y-221X) and low MBL levels are associated with susceptibility to multi organ dysfunction in P. falciparum malaria in Odisha, India.甘露聚糖结合凝集素2（MBL-2）基因多态性（密码子54和Y-221X）以及低MBL水平与印度奥里萨邦恶性疟原虫疟疾患者发生多器官功能障碍的易感性相关。
Front Microbiol. 2015 Jul 31;6:778. doi: 10.3389/fmicb.2015.00778. eCollection 2015.
9
Immunopathogenesis of lymphatic filarial disease.淋巴丝虫病的免疫发病机制。
Semin Immunopathol. 2012 Nov;34(6):847-61. doi: 10.1007/s00281-012-0346-4. Epub 2012 Oct 3.
10
Heightened measures of immune complex and complement function and immune complex-mediated granulocyte activation in human lymphatic filariasis.在人类淋巴丝虫病中，免疫复合物和补体功能以及免疫复合物介导的粒细胞激活的措施得到了增强。
Am J Trop Med Hyg. 2011 Jul;85(1):89-96. doi: 10.4269/ajtmh.2011.11-0086.
本文引用的文献
1
The global programme to eliminate lymphatic filariasis: health impact after 8 years.全球消除淋巴丝虫病规划：8 年后的健康影响。
PLoS Negl Trop Dis. 2008 Oct 8;2(10):e317. doi: 10.1371/journal.pntd.0000317.
2
Mannose-binding lectin A-deficient mice have abrogated antigen-specific IgM responses and increased susceptibility to a nematode infection.甘露糖结合凝集素A缺陷型小鼠的抗原特异性IgM反应被消除，对线虫感染的易感性增加。
J Immunol. 2007 Apr 15;178(8):5116-23. doi: 10.4049/jimmunol.178.8.5116.
3
Bancroftian filariasis: house-to-house variation in the vectors and transmission -- and the relationship to human infection -- in an endemic community of coastal Tanzania.班氏丝虫病：坦桑尼亚沿海一个流行社区中病媒及传播的逐户差异——以及与人类感染的关系
Ann Trop Med Parasitol. 2007 Jan;101(1):51-60. doi: 10.1179/136485907X154610.
4
Influence of candidate susceptibility genes on tuberculosis in a high endemic region.高流行地区候选易感基因对结核病的影响。
Mol Immunol. 2007 Mar;44(9):2213-20. doi: 10.1016/j.molimm.2006.11.002. Epub 2006 Dec 6.
5
Human bancroftian filariasis: immunological markers of morbidity and infection.人类班氏丝虫病：发病和感染的免疫标志物
Microbes Infect. 2006 Aug;8(9-10):2414-23. doi: 10.1016/j.micinf.2006.05.003. Epub 2006 Jun 9.
6
Mannose-binding lectin and its genetic variants.甘露糖结合凝集素及其基因变体。
Genes Immun. 2006 Mar;7(2):85-94. doi: 10.1038/sj.gene.6364283.
7
Rapid screening for glucose-6-phosphate dehydrogenase deficiency and haemoglobin polymorphisms in Africa by a simple high-throughput SSOP-ELISA method.采用简单的高通量序列特异性寡核苷酸-酶联免疫吸附测定法对非洲葡萄糖-6-磷酸脱氢酶缺乏症和血红蛋白多态性进行快速筛查。
Malar J. 2005 Dec 15;4:61. doi: 10.1186/1475-2875-4-61.
8
The dynamics of Wuchereria bancrofti infection: a model-based analysis of longitudinal data from Pondicherry, India.班氏吴策线虫感染的动态变化：基于模型对印度本地治里纵向数据的分析
Parasitology. 2004 May;128(Pt 5):467-82. doi: 10.1017/s0031182004004822.
9
Clustering of filarial infection in an age-graded study: genetic, household and environmental influences.年龄分层研究中丝虫感染的聚集性：遗传、家庭及环境影响
Parasitology. 2004 Mar;128(Pt 3):315-21. doi: 10.1017/s0031182003004487.
10
A 26-year follow-up of bancroftian filariasis in two communities in north-eastern Tanzania.坦桑尼亚东北部两个社区班氏丝虫病的26年随访
Ann Trop Med Parasitol. 2004 Mar;98(2):155-69. doi: 10.1179/000349804225003172.
Zotero 插件