Clinical trial of thiamphenicol therapy for uncomplicated gonorrhea.

The need for a safe drug that is easy to administer and not too expensive prompted a study of treatment of uncomplicated gonorrhea with a single oral dose of 2.5 g of thiamphenicol. Of 169 patients treated, 161 were cured. Of the 92 patients with acute infections, all of the 13 men and 74 (93.7%) of the 79 women were cured. Seventy-seven cases were defined as reinfection; all of the 22 men in this group were cured, as were 52 (94.5%) of the 55 women. Only minor adverse effects were noted. It is concluded that thiamphenicol is a safe and effective antibiotic for therapy of uncomplicated gonorrhea.